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What is sibutramine? What is sibutramine used for?

Sibutramine is no longer available in the U.S. because of the risk of serious cardiovascular problems in some people who take it.

Sibutramine is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced-calorie diet.

Sibutramine is recommended for obese patients with an initial body mass index ≥ 30 kg/m2, or ≥ 27 kg/m2 in the presence of other risk factors (e.g., diabetes, dyslipidemia, controlled hypertension).

What brand names are available for sibutramine?
Meridia

Is sibutramine available as a generic drug?
No

Do I need a sibutramine prescription?
Yes

What are the side effects of sibutramine?

Sibutramine substantially increases blood pressure and/or pulse rate in some patients. Regular monitoring of blood pressure and pulse rate is required when prescribing sibutramine.

What is sibutramine?

Sibutramine was withdrawn from the U.S. market in October 2010.

Sibutramine affects chemicals in the brain that affect weight maintenance.

Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.

Sibutramine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about sibutramine?

Sibutramine was withdrawn from the U.S. market in October 2010.

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body.

You should not take sibutramine if you are allergic to it, or if you have severe or uncontrolled high blood pressure, an eating disorder (anorexia or bulimia), if you are taking stimulant diet pills, or if you have a history of coronary artery disease, stroke, or heart disease.

Before taking sibutramine, tell your doctor if you have glaucoma, high blood pressure, liver or kidney disease, depression, underactive thyroid, seizures, a bleeding disorder, a history of gallstones, or if you are older than 65 or younger than 16.

Tell your doctor about all prescription and over-the-counter medications you use, especially antidepressants, cold or allergy medication, narcotic pain medicine, or migraine headache medicines.

Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks along with a low calorie diet.

What should I discuss with my healthcare provider before taking sibutramine?

You should not take this medication if you are allergic to sibutramine, or if you have:

· severe or uncontrolled hypertension (high blood pressure);

· an eating disorder (anorexia or bulimia);

· a history of coronary artery disease (atherosclerosis);

· a history of heart disease (congestive heart failure, heart rhythm disorder);

· a history of heart attack or stroke; or

· if you are taking stimulant diet pills.

If you have any of these other conditions, you may need a sibutramine dose adjustment or special tests:

· glaucoma;

· high blood pressure;

· liver disease;

· kidney disease;

· depression;

· underactive thyroid;

· epilepsy or seizure disorder;

· a bleeding or blood clotting disorder;

· a history of gallstones; or

· if you are older than 65 or younger than 16.

FDA pregnancy category C. It is not known whether sibutramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using sibutramine.

It is not known whether sibutramine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to anyone younger than 16 years old.

How should I take sibutramine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Sibutramine is usually taken once daily. Follow your doctor's instructions.

Your doctor may occasionally change your dose to make sure you get the best results.

Sibutramine can be taken with or without food.

You should lose at least 4 pounds during the first 4 weeks of taking sibutramine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks.

Your blood pressure and pulse will need to be checked often. Visit your doctor regularly.

Sibutramine should not be taken for longer than 2 years.

Store at room temperature away from moisture, heat, and light.

Do not share sibutramine with another person. Keep the medication in a place where others cannot get to it.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, dizziness, and fast heart rate.

What should I avoid while taking sibutramine?

Sibutramine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not take any other prescription or over-the-counter weight-loss products without your doctor's advice.

Avoid taking cough and cold or allergy medications while taking sibutramine.

Avoid drinking alcohol while taking sibutramine.

Sibutramine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sibutramine and call your doctor at once if you have a serious side effect such as:

· fast, pounding, or uneven heartbeats;

· new or worsening shortness of breath;

· agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;

· very stiff (rigid) muscles, high fever, sweating, confusion, feeling like you might pass out;

· easy bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);

· dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, seizure);

· chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling; or

· sudden numbness or weakness (especially on one side of the body), problems with vision, speech, or balance.

Less serious side effects may include:

· dry mouth, upset stomach;

· changes in appetite;

· constipation, stomach pain;

· headache, back pain, joint pain;

· feeling nervous, dizzy, or depressed;

· flu symptoms, runny or stuffy nose, sore throat, cough;

· warmth, redness, or tingly feeling under your skin;

· trouble sleeping (insomnia); or

· mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sibutramine dosing information

Usual Adult Dose for Obesity:

Sibutramine was voluntarily withdrawn from the US market by the manufacturer in October, 2010 due to clinical trial data indicating an increased risk of heart attack and stroke. The following dosage information applies to when the drug was available in the US.

Initial Dose: 10 mg orally once a day.

Usual Geriatric Dose for Obesity:

Usual Pediatric Dose for Obesity:

What other drugs will affect sibutramine?

Before using sibutramine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by sibutramine.

Ask your doctor before taking any decongestants, cough medicine, or other diet pills.

The following drugs can interact with sibutramine. Tell your doctor if you are using any of these:

· lithium (Lithobid, Eskalith, and others);

· tryptophan or L-tryptophan;

· ketoconazole (Nizoral);

· an antibiotic such as erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);

· an antidepressant such as citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), and others;

· ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine).

· migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or

· narcotic pain medication such as fentanyl (Actiq, Duragesic, Fentora, Onsolis), meperidine (Demerol), pentazocine (Talwin).

This list is not complete and other drugs may interact with sibutramine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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